Probing structures of large protein complexes using zero-length cross-linking
نویسندگان
چکیده
منابع مشابه
Visualizing the Ensemble Structures of Protein Complexes Using Chemical Cross-Linking Coupled with Mass Spectrometry
GRAPHICAL ABSTRACT ABSTRACT Chemical cross-linking coupled with mass spectrometry (CXMS) identifies protein residues that are close in space, and has been increasingly used for modeling the structures of protein complexes. Here we show that a single structure is usually sufficient to account for the intermolecular cross-links identified for a stable complex with sub-µmol/L binding affinity. ...
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ژورنال
عنوان ژورنال: Methods
سال: 2015
ISSN: 1046-2023
DOI: 10.1016/j.ymeth.2015.04.031